The present study was conducted to analyze the effect of coenzyme Q10 treatment in 48 patients with myocardial injury caused by acute organophosphorus poisoning admitted to our hospital. It was found that coenzyme Q10 could play a significant role in the repair of myocardial injury caused by acute organophosphorus poisoning.
In this study, 48 patients with myocardial injury in acute organophosphorus poisoning admitted to our hospital were taken as research subjects to analyze the effect of coenzyme Q10 treatment.
Abstrac:Objective To explore the effect of coenzyme Q10 on patients with acute organophosphorus poisoning myocardial injury. Methods The research subjects were 48 patients with acute organophosphorus poisoning myocardial injury in our hospital, who were admitted to our hospital and received treatment between August 2016 and August 2017, and were equally divided into two groups, i.e., the conventional group and the research group, with 24 cases in each group by computer randomization. The conventional group received comprehensive treatment and the study group received comprehensive treatment + coenzyme Q10. Before treatment, the serum concentrations of cardiac enzymes such as CK, LDH, CK-MB and AST were not statistically significant when comparing the two groups (P＞0.05); after treatment, the indicators of CK, LDH, CK-MB and AST in the research group were significantly lower than those in the conventional group, which was statistically significant (P＜0.05). Conclusion Coenzyme Q10 can play a significant role in repairing myocardial injury caused by acute organophosphorus poisoning.
1 Information and methodology
1.1 General information
The study subjects were 48 patients with acute organophosphorus poisoning myocardial injury, who were admitted to our hospital between August 2016 and August 2017 and received treatment. According to the AOPP classification and diagnostic criteria proposed in the eighth edition of Internal Medicine, the degree of poisoning was categorized as moderately severe and mild. Among them, 33 cases were moderately severe and 15 cases were mild. In the case of dermal poisoning, there were 13 cases of dermal poisoning and 35 cases of oral poisoning. There were 16 cases of dichlorvos poisoning, 9 cases of oxolinic acid poisoning, 10 cases of methamidophos poisoning, 10 cases of parathion poisoning and 3 cases of others. By computerized randomization, the patients were equally divided into two groups, i.e., conventional group and study group, with 24 cases in each of the two groups. In the study group, there were 10 male and 14 female subjects aged 20-60 (40.1±8.7) years; in the conventional group, there were 12 male and 12 female subjects aged 22-62 (40.2±8.9) years. Comparing the clinical data of the two groups, the results were not statistically significant (P＞0.05) and were comparable.
1.2 Methodology
The conventional group received comprehensive treatment, i.e., repeated gastric lavage, thorough gastric lavage, fluid supplementation to promote metabolism, diarrhea, and symptomatic treatment with cholinesterase reenactors and the anticholinergic drug atropine.
The study group received combination therapy + coenzyme Q10 by taking 10 mg of coenzyme Q10 , 1x/d IV, and adhering to the medication for 1 week.
1.3 Observation indicators
Venous blood was collected on admission and after 1 week of treatment, and biochemical tests were performed to determine serum concentrations of cardiac enzymes, including CK (serum creatine kinase), LDH (lactate dehydrogenase), CK-MB (serum creatine kinase isoenzyme), and AST (aspartate aminotransferase).
1.4 Statistical analysis
SPSS 21.0 statistical software was used to analyze the data. Measurements were expressed as "x ± s", and t-test was used, and the difference was considered statistically significant at P＜0.05.
2 Results
Before treatment, comparing the serum concentrations of cardiac enzymes such as CK, LDH, CK-MB, AST and other enzymes in the two groups, there was no statistical significance (P＞0.05); after treatment, the indicators of CK, LDH, CK-MB, and AST in the research group were significantly reduced, and lower than those in the conventional group, which was statistically significant (P＜0.05). See Table 1.
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panel | CK | LDH | CK-MB | AST | ||||
pre-treatment | post-treatment | pre-treatment | post-treatment | pre-treatment | post-treatment | pre-treatment | post-treatment | |
Study group (n=24) | 556±106 | 62±30 | 561±121 | 100±33 | 71±25 | 16±5 | 95±16 | 30±8 |
Conventional group (n=24) | 557±107 | 101±31 | 570±120 | 175±54 | 72±26 | 20±7 | 97±15 | 41±6 |
t | 0.032 | 4.428 | 0.258 | 5.805 | 0.135 | 2.277 | 0.446 | 5.388 |
P | 0.974 | 0.000 | 0.797 | 0.000 | 0.892 | 0.027 | 0.657 | 0.000 |
Table 1 Comparison of the two groups in terms of fluid resuscitation by rehydration to the time of surgery (x ± s)
groups | number of examples | Time from rehydration to surgery (h) | Liquid resuscitation volume (mL) |
test group | 78 | 2.0±0.3 | 1240.5±253.1 |
control subjects | 77 | 2.5±0.4 | 2550.6±420.3 |
t |
| 8.811 | 23.543 |
P |
| 0.000 | 0.000 |
2.2 Comparison of Resuscitation Effectiveness
Comparison of resuscitation success rate of the experimental group was higher than that of the control group (P < 0.05), death
The rate and MOD occurrence` rate were lower in the experimental group than in the control group (P < 0.05), see Table 2.
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